History will record the Human Genome Project as one of the top accomplishments of the 20th century. All 3,000,000,000 base pairs in the approximately 20,000 to 25,000 genes have been sequenced. How did biologists determine the sequence of all those base pairs? With the simplified models used in this simulation, students will be able to discover the principles involved in the DNA sequencing process. The Sanger termination principle will be graphically illustrated with the cutout models in this hands-on activity. The models will provide an excellent review of DNA structure and the model manipulations will extend student understanding of the anti-parallel nature of DNA.Enough model materials are provided for 30 students working in pairs. Student materials and detailed teacher materials are included.