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Any change in the pH of a protein’s environment will cause observable changes in its solubility that reflect changes in the three-dimensional structure of the protein. With the pH and Protein Solubility: A Reversible Demonstration—ChemTopic™ Lab Activity, examine the effect of pH on the solubility and structure of casein, a milk protein. Available as part of the Biochemistry: The Molecules of Life—ChemTopic™ Labs digital collection. Click the Price link for digital collection pricing.