FlinnPREP™ Inquiry Labs for AP® Chemistry: Separating a Synthetic Pain Relief Mixture
By: The Flinn Staff
Item #: AP7662
The Separating a Synthetic Pain Relief Mixture Inquiry Lab Solution for AP® Chemistry explores physical properties of a synthetic mixture to determine its percent composition while integrating solubility and acid–base reaction concepts.
Includes access to exclusive FlinnPREP™ digital content to combine the benefits of classroom, laboratory and digital learning. Each blended learning lab solution includes prelab videos about concepts, techniques and procedures, summary videos that relate the experiment to the AP® exam, built-in student lab safety training with assessments, and standards-based, tested inquiry labs with real sample data. FlinnPREP™ Inquiry Lab Solutions are adaptable to you and how you teach with multiple ways to access and run your AP® labs.
Big Idea 3, Investigation 9, Primary Learning Objective 3.10
Most over-the-counter (OTC) drugs are mixtures of active drug ingredient(s) and binders with a variable composition. Investigate the physical properties of ingredients in a synthetic pain relief mixture and determine its percent composition.
In the introductory activity, students test the solubility of each possible OTC component in ethyl acetate and in an aqueous solution of sodium bicarbonate. Using these results, students design of a flow chart procedure to separate the components and determine the amount of each. Optional extension activities include varying the composition of the OTC mixtures and analyzing consumer samples. Students may also measure the melting points of the isolated components to confirm their identity.
This advanced inquiry lab integrates student understanding of solubility and acid–base chemical reactions.
Complete for 24 students working in pairs. Perform this experiment in a fume hood or well-ventilated lab.
Materials Included in Kit: Acetaminophen, 15 g Acetylsalicylic acid, 15 g Ethyl acetate, 200 mL, 4 Hydrochloric acid solution, 6 M, 250 mL, 2 Silica gel, 36–60 mesh, 5 g Sodium bicarbonate solution, 10%, 300 mL, 2 Hydrion® 1–12 pH test strips
Additional Materials Required (for each lab group): 0.001-g precision balance (shared), beakers, boiling stones, capillary tubes (optional), Erlenmeyer flask, filter paper, funnel, graduated cylinder, hot plate, ice bath, magnetic stirrer and stir bar or stirring rod, melting point apparatus (optional), separatory funnel, spatula, support stand and ring clamp, test tubes, watch glasses, weighing dishes.
*AP is a registered trademark of the College Board, which was not involved in the production of, and does not endorse, this product.
Correlation to Next Generation Science Standards (NGSS)†
Science & Engineering Practices
Developing and using models Planning and carrying out investigations Analyzing and interpreting data Using mathematics and computational thinking
Disciplinary Core Ideas
HS-PS1.A: Structure and Properties of Matter
Scale, proportion, and quantity Structure and function
HS-PS1-3. Plan and conduct an investigation to gather evidence to compare the structure of substances at the bulk scale to infer the strength of electrical forces between particles. HS-PS2-6. Communicate scientific and technical information about why the molecular-level structure is important in the functioning of designed materials.