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Synthesis of Aspirin: From Natural Products to Painkillers—ChemTopic™ Lab Activity

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Aspirin is one of the oldest yet most common drugs in use today. Aspirin has its roots in an ancient folk remedy—using willow extracts to treat fever and pain and is prepared the same way today that it was more than 100 years ago. With the Synthesis of Aspirin: From Natural Products to Painkillers—ChemTopic™ Lab Activity, prepare acetylsalicylic acid (aspirin), determine its purity and investigate its chemical properties.

Concepts

  • History of aspirin
  • Esters and esterification
  • Salicylic acid derivatives
  • Excess and limiting reagents