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Product 14279

By: The Flinn Staff

In the Magnetic Karyotypes Genetics Demonstration Kit for biology and life science, learn to identify and classify chromosome smears according to the Denver system.

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Teach students to identify and classify chromosome smears according to the Denver System using large magnetic demonstration models of chromosomes! Begin by building a karyotype of a normal male and a normal female on your magnetic classroom board. Investigate the karyotypes of eight different chromosomal abnormalities. These conditions include Down’s Syndrome (Trisomy 21), Edward’s Syndrome (Trisomy 18), Patau Syndrome (Trisomy 13), Klinefelter’s Syndrome, Disomy Y, Triple X (Trisomy X), Turner Syndrome (Monosomy X) and Robertson Translocation. Kit contains one 12" × 36" magnet with copies of all chromosomes necessary to perform this demonstration. Chromosomes may easily be cut from the magnet using a paper cutter and/or scissors.

Concepts: Chromosome smear, karotyping, chromosonal abnormalities, homologous chromosomes.
Time Required: One class period
Materials Provided: Denver System Template, magnetic chromosomes.

Correlation to Next Generation Science Standards (NGSS)

Science & Engineering Practices

Asking questions and defining problems
Developing and using models
Constructing explanations and designing solutions

Disciplinary Core Ideas

MS-LS1.A: Structure and Function
MS-LS3.A: Inheritance of Traits
MS-LS3.B: Variation of Traits
HS-LS1.A: Structure and Function
HS-LS3.A: Inheritance of Traits
HS-LS3.B: Variation of Traits

Crosscutting Concepts

Patterns
Cause and effect
Scale, proportion, and quantity
Systems and system models
Structure and function
Stability and change

Performance Expectations

MS-LS1-5. Construct a scientific explanation based on evidence for how environmental and genetic factors influence the growth of organisms.
MS-LS3-1. Develop and use a model to describe why structural changes to genes (mutations) located on chromosomes may affect proteins and may result in harmful, beneficial, or neutral effects to the structure and function of the organism.
HS-LS1-1. Construct an explanation based on evidence for how the structure of DNA determines the structure of proteins, which carry out the essential functions of life through systems of specialized cells.
HS-LS3-1. Ask questions to clarify relationships about the role of DNA and chromosomes in coding the instructions for characteristic traits passed from parents to offspring.
HS-LS3-2. Make and defend a claim based on evidence that inheritable genetic variations may result from (1) new genetic combinations through meiosis, (2) viable errors occurring during replication, and/or (3) mutations caused by environmental factors.