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Product 14191

By: The Flinn Staff

In the Recombinant DNA Laboratory Kit for biotechnology, simulate the roles of restriction enzymes and DNA ligase In the formation of recombinant DNA.

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Bring microscopic genetic techniques to life size by building a recombinant DNA plasmid! Simulate the roles of restriction enzymes and DNA ligase in the formation of recombinant DNA. Students will construct plasmid DNA using chenille wire and four different colored pony beads—each representing a different nitrogenous base. Students will manipulate the plasmid by locating restriction sites and cutting the chenille wire as the restriction enzyme would do to the plasmid. They will then insert genes of interest using pony beads, and twist the wire back together to simulate ligating the plasmid. Includes a pre-lab, paper-and-pencil activity to familiarize students with the process of forming recombinant DNA molecules before beginning the activity. Complete with enough reusable materials for 30 students working in pairs, or 15 groups of students. Also includes reproducible student handouts as well as complete Teacher Notes.

Correlation to Next Generation Science Standards (NGSS)

Science & Engineering Practices

Asking questions and defining problems
Developing and using models
Planning and carrying out investigations
Constructing explanations and designing solutions
Engaging in argument from evidence

Disciplinary Core Ideas

HS-LS1.A: Structure and Function
HS-LS3.A: Inheritance of Traits
HS-LS3.B: Variation of Traits

Crosscutting Concepts

Patterns
Cause and effect
Systems and system models
Structure and function

Performance Expectations

HS-LS1-1. Construct an explanation based on evidence for how the structure of DNA determines the structure of proteins, which carry out the essential functions of life through systems of specialized cells.
HS-LS3-1. Ask questions to clarify relationships about the role of DNA and chromosomes in coding the instructions for characteristic traits passed from parents to offspring.